Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models

Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models

Objective: Parkinson's disease (PD) pathophysiology is associated with a progressive loss of dopaminergic neurons in the substantia nigra and accumulation of insoluble inclusions of misfolded alpha-synuclein. In this study, we used a neuroblastoma-derived cell model overexpressing a pro-aggrega...

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Main Authors: Sara Lucas-Del-Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, Carlos Lazaro-Hernandez, Kai-Yin Chau, Derralynn A. Hughes, Anthony H.V. Schapira
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Alpha-synuclein
TFEB
PIKfyve
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002694
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