Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury

Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury

Abstract Microglia play significant roles in spinal cord injury (SCI) progression. Previous studies have suggested that ferroptosis plays a crucial role in exacerbating neuronal death following SCI; however, the role of microglial ferroptosis in SCI and the underlying mechanisms remain elusive. Here...

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Main Authors: Pengfei Bie, Dongpo Su, Yang Gao, Liang Wu, Zhanfeng Niu, Yanbin Zhao, He He, Zhanfeng Jiang, Zhong Zeng, Yaolin Zhang, Heng Fan, Hechun Xia
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08664-x
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https://doi.org/10.1038/s42003-025-08664-x

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