A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes. In this study, we introduced mRNAs into oligo...

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Main Authors: Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
mRNA therapy
oligodendrocyte
Krabbe disease
lipid nanoparticles
drug delivery system
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124002671
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http://www.sciencedirect.com/science/article/pii/S2162253124002671

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