Mitochondrial DNA copy number as a mediator of the relationship between insulin resistance and cognitive function in patients with euthymic bipolar disorder

Mitochondrial DNA copy number as a mediator of the relationship between insulin resistance and cognitive function in patients with euthymic bipolar disorder

Abstract Persistent cognitive challenges in bipolar disorder (BD) may be tied to insulin resistance, which crucially affects both metabolism and brain health. Additionally, mitochondrial DNA (mtDNA) copy number has emerged as an indicator of cognitive performance and response to treatment in BD. How...

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Bibliographic Details
Main Authors: Tsung Han Tsai, Cheng Ying Wu, Cheng Chen Chang, Ta Tsung Lin, Chin San Liu, Po See Chen
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
bipolar disorder
cognition
executive function
insulin resistance
mitochondrial DNA copy number
Online Access:https://doi.org/10.1002/kjm2.12914
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