Mechanistic insights into the mitigating role of beta-caryophyllene on cadmium-induced liver injury
Cadmium (Cd) is a toxic heavy metal that can cause severe hepatotoxicity in the body. This study investigates the hepatoprotective effects of Beta-Caryophyllene (BCP), a natural sesquiterpene, against Cd-induced liver injury. In the study, the protective effects of BCP on biological processes such a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2025-08-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=3212 |
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| Summary: | Cadmium (Cd) is a toxic heavy metal that can cause severe hepatotoxicity in the body.
This study investigates the hepatoprotective effects of Beta-Caryophyllene (BCP), a
natural sesquiterpene, against Cd-induced liver injury. In the study, the protective
effects of BCP on biological processes such as oxidative stress, inflammation and
apoptosis were investigated through TLR4/NF-κB, SIRT1/KEAP1/Nrf2/HO-1 and Bax/
Bcl-2/Caspase3 signaling pathways. For this purpose, 50 male rats were divided into
5 groups: Control, Cd, BCP100+Cd, BCP200+Cd and BCP200, 10 in each group. At
the end of the study, it was determined that Cd exposure caused damage to cells by
increasing lipid peroxidation, oxidative stress and inflammation in liver tissue. However,
BCP treatment was found to reduce oxidative damage by increasing antioxidant enzyme
activities (SOD, GSH, CAT) and reducing lipid peroxidation (MDA). Furthermore, it
was determined that BCP lowered proinflammatory cytokine levels (TNF-α, IL-1β) by
inhibiting TLR4/NF-κB signaling activity, while also increasing anti-inflammatory IL-
10 levels. It was also observed that BCP inhibits the suppression of Nrf2 through KEAP1
by activating the Nrf2 signaling pathway, resulting in elevated levels of SIRT and HO-1.
In the analyses of apoptosis, it was determined that BCP inhibited Caspase3 activity and
reduced apoptosis in liver cells by balancing the Bax/Bcl-2 ratio. These findings suggest
that BCP provides potent protection against Cd-induced liver toxicity by regulating
various signaling pathways and could potentially be used as a hepatoprotective agent. |
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| ISSN: | 1309-2251 |