Analysis of single-cell RNA sequencing in human oocytes with diminished ovarian reserve uncovers mitochondrial dysregulation and translation deficiency

Analysis of single-cell RNA sequencing in human oocytes with diminished ovarian reserve uncovers mitochondrial dysregulation and translation deficiency

Abstract Background Diminished ovarian reserve (DOR) is clinically characterized by a decrease in the number of available ovarian follicles and a decline in the quality of oocytes, accompanied by hormonal changes. Low quality of DOR oocyte leads to impaired embryo development, an increased risk of a...

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Main Authors: Xin Li, Xingwu Wu, Hui Zhang, Peipei Liu, Leizhen Xia, Nana Zhang, Lifeng Tian, Zengming Li, Jing Lu, Yan Zhao, Jun Tan
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Reproductive Biology and Endocrinology
Subjects:
Oocyte
DOR
PLAG1
IGF2
Translation
Mitochondrial function
Online Access:https://doi.org/10.1186/s12958-024-01321-8
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https://doi.org/10.1186/s12958-024-01321-8

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