Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins

Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins

Abstract Cell‐to‐cell transmission of protein aggregates is an emerging theme in neurodegenerative disease. Here, we analyze the dipeptide repeat (DPR) proteins that form neuronal inclusions in patients with hexanucleotide repeat expansion C9orf72, the most common known cause of amyotrophic lateral...

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Bibliographic Details
Main Authors: Qihui Zhou, Carina Lehmer, Meike Michaelsen, Kohji Mori, Dominik Alterauge, Dirk Baumjohann, Martin H Schludi, Johanna Greiling, Daniel Farny, Andrew Flatley, Regina Feederle, Stephanie May, Franziska Schreiber, Thomas Arzberger, Christoph Kuhm, Thomas Klopstock, Andreas Hermann, Christian Haass, Dieter Edbauer
Format: Article
Language:English
Published: Springer Nature 2017-03-01
Series:EMBO Molecular Medicine
Subjects:
amyotrophic lateral sclerosis
C9orf72
immunotherapy
RAN translation
seeding
Online Access:https://doi.org/10.15252/emmm.201607054
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https://doi.org/10.15252/emmm.201607054

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