Perturbation of enzyme structure by nano-metal organic frameworks: A question mark on their safety-by-design?

Perturbation of enzyme structure by nano-metal organic frameworks: A question mark on their safety-by-design?

Our study investigates the interactions between nanoscale Metal-Organic Frameworks (nMOFs), specifically ZIF-8 and CuIm, and key enzymes: Acetylcholine Esterase (AChE), α-amylase. Using circular dichroism (CD) spectroscopy, we observed significant alterations in the secondary structures of these enz...

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Bibliographic Details
Main Authors: Swaroop Chakraborty, Bashiru Ibrahim, Pankti Dhumal, Nathan Langford, Lauren Garbett, Eugenia Valsami-Jones
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Hazardous Materials Letters
Subjects:
Metal Organic Framework
Nanomaterials
Safety-By-Design
Enzyme Perturbation
MOF Toxicity
MOF-Enzyme interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S2666911024000261
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