Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues

Abstract Formalin-fixed paraffin-embedded (FFPE) samples represent a vast, untapped resource for epigenomic research, yet molecular tools for deep analysis of these specimens remain limited. We introduce spatial FFPE-ATAC-seq, an approach for in situ profiling chromatin accessibility within archived...

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Bibliographic Details
Main Authors: Pengfei Guo, Yufan Chen, Liran Mao, Angelysia Cardilla, Chin Nien Lee, Yan Cui, Dengge Jin, Yucong Hua, Xiaowei Xu, Yanxiang Deng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60882-3
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