NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors

NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors

IntroductionT cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of cytokines. Some of the major obstacles to cellular immunotherapy in solid tumors include inefficient cell inf...

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Main Authors: Cheng Wei, Xin Huang, Tianlong Xu, Yinan Fang, Fabao Wang, Qiaolin He, Peiyuan Zhang, Qianjin Yu, Ying Zhang, Binjiao Zheng, Yue Gao, Yongping Chen, Qichuan Zhuge, Ai Zhao, Jimin Gao, Jinhong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
T cell Antigen Coupler (TAC-T)
CD28
NECTIN-4
solid tumor
adoptive cell transfer therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456443/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456443/full

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