Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets

Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets

Abstract Background The molecular landscape of lung neuroendocrine neoplasms is still poorly characterized, making it difficult to develop a molecular classification and personalized therapeutic approaches. Significant clinical heterogeneity of these malignancies has been highlighted among poorly di...

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Main Authors: Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia, Andrea Marcello Isidori, Antongiulio Faggiano, Rita Mancini, Claudia De Vitis
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Lung neuroendocrine tumors
Carcinoids
Next generation sequencing
Somatic mutation
Germline mutation
Whole exome sequencing
Online Access:https://doi.org/10.1186/s12967-025-06442-1
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https://doi.org/10.1186/s12967-025-06442-1

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