The minor allele rs2295613(A), protective against systemic lupus erythematosus, makes a differential contribution to the activity of the <i>SLAMF1</i> gene promoter in T helpers and in regulatory T lymphocytes

The minor allele rs2295613(A), protective against systemic lupus erythematosus, makes a differential contribution to the activity of the <i>SLAMF1</i> gene promoter in T helpers and in regulatory T lymphocytes

SLAMF1 (CD150) is a receptor expressed on various hematopoietic cells and involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). This disorder is a chronic autoimmune inflammatory disease characterized by dysregulation of B lymphocytes, production of a large...

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Main Authors: A. N. Uvarova, L. V. Putlyaeva, E. A. Zheremyan, E. M. Stasevich, M. M. Murashko, E. A. Bogomolova, K. V. Korneev, D. E. Demin, A. M. Schwartz, D. V. Kuprash
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2025-06-01
Series:Медицинская иммунология
Subjects:
transcription regulation
slamf1
snp
t cells
sle
Online Access:https://www.mimmun.ru/mimmun/article/view/3241
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