Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single‐Cell Level

Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single‐Cell Level

Abstract Heterotopic ossification (HO), often arising in response to traumatic challenges, results from the aberrant osteochondral differentiation of mesenchymal stem cells (MSCs). Nevertheless, the impact of trauma‐induced inflammatory exposure on MSC fate determination remains ambiguous. In this s...

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Main Authors: Chen Kan, Zhenya Tan, Haitao Wang, Wei Wang, Jiazhao Yang, Ya Zhang, Xiaoling Lu, Qirong Cheng, Lanyi Chai, Chao Peng, Jicheng Zhu, Chenghang Zhu, Hailin Wang, Li Zhan, Keqiong Lin, Yakun Liu, Lingqiang Zhang, Haitao Fan, Hong Zheng
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
heterotopic ossification
inflammatory microenvironment
mesenchymal stem cells
osteoimmunology
Online Access:https://doi.org/10.1002/advs.202310282
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https://doi.org/10.1002/advs.202310282

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