Single-cell and bulk transcriptome sequencing identifies circadian rhythm disruption and cluster-specific clinical insights in colorectal tumorigenesis

Single-cell and bulk transcriptome sequencing identifies circadian rhythm disruption and cluster-specific clinical insights in colorectal tumorigenesis

Abstract Background Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system worldwide, with its mortality ranking second among all cancers. Studies have indicated that disruptions in circadian rhythm (CR) are associated with the occurrence of various cancers; howev...

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Bibliographic Details
Main Authors: Chen Liu, Jingyang Liu, Jing Shao, Xiaoman Zhao, Lin Xie, Mengyao Shang, Ying Li, Weiming Li
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Colorectal cancer
Circadian rhythm
Immune checkpoint blockade therapy
Single-cell RNA sequencing
Prognostic model
Online Access:https://doi.org/10.1007/s12672-025-02521-3
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https://doi.org/10.1007/s12672-025-02521-3

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