Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy
ABSTRACT Background Hypocalcemia is a relatively common complication after parathyroidectomy for treatment of primary hyperparathyroidism. Objectives To retrospectively evaluate clinical variables in dogs with primary hyperparathyroidism to determine whether or not an association exists between pre‐...
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Wiley
2025-03-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.70016 |
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| author | Victoria Travail Claudio Motta Charlotte Lea Andres Salas‐Garcia Katherine Clarke Sergio Federico Lombardo Amanda Paul Dorothy Hajdu Carla Asorey Blázquez Mayank Seth Michelle Walton‐Clark Luis Miguel Garcia Roldan Rebecca Frances Geddes Sophie Allison Conway Katia Sánchez González Paula García Domínguez Sophie Keyte Danica Pollard Darren Kelly |
| author_facet | Victoria Travail Claudio Motta Charlotte Lea Andres Salas‐Garcia Katherine Clarke Sergio Federico Lombardo Amanda Paul Dorothy Hajdu Carla Asorey Blázquez Mayank Seth Michelle Walton‐Clark Luis Miguel Garcia Roldan Rebecca Frances Geddes Sophie Allison Conway Katia Sánchez González Paula García Domínguez Sophie Keyte Danica Pollard Darren Kelly |
| author_sort | Victoria Travail |
| collection | DOAJ |
| description | ABSTRACT Background Hypocalcemia is a relatively common complication after parathyroidectomy for treatment of primary hyperparathyroidism. Objectives To retrospectively evaluate clinical variables in dogs with primary hyperparathyroidism to determine whether or not an association exists between pre‐surgical variables and the development of post‐surgical hypocalcemia. Animals One hundred three dogs diagnosed with primary hyperparathyroidism and treated by parathyroidectomy in seven referral hospitals between 2010 and 2021. Material and Methods Data collected from medical records included signalment, physical examination findings, concurrent illnesses, ongoing medications, and clinicopathologic test results (including serum ALP activity, iCa, plasma phosphate and PTH concentrations). Dogs were assigned into groups based on lowest iCa post‐surgery: Group1 ≥ 1.1 mmol/L, Group2 < 1.1 mmol/L. The Mann–Whitney U test assessed associations between several variables of interest and the occurrence of post‐surgery hypocalcemia. ROC analyses were performed to identify variables that had the potential to predict the development of hypocalcemia after surgery. Results The median plasma PTH concentration pre‐surgery in dogs which developed hypocalcemia after surgery was significantly higher (232 pg/mL {[IQR] 108–421}) than in dogs which did not develop hypocalcemia after surgery (81.5 pg/mL {IQR 58.5–145.0}; p < 0.001). Plasma PTH concentration had a fair to good ability to predict the development of post‐surgery hypocalcemia, with AUC being 0.78 [95% confidence interval 0.67–0.89]. Using a cut‐off of ≥ 75 pg/mL, pre‐surgery plasma PTH concentration had a sensitivity of 96.6% and specificity of 42.3% for the development of post‐surgery hypocalcemia. Dogs that developed hypocalcemia after surgery were older and had lower body weights. Conclusion Pre‐surgery plasma PTH concentrations might be helpful in predicting those dogs at risk of developing hypocalcemia after parathyroidectomy. |
| format | Article |
| id | doaj-art-a57a6f36e7dc41cc8fa0e8c818ee7d3e |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-a57a6f36e7dc41cc8fa0e8c818ee7d3e2025-08-20T03:48:56ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-03-01392n/an/a10.1111/jvim.70016Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With ParathyroidectomyVictoria Travail0Claudio Motta1Charlotte Lea2Andres Salas‐Garcia3Katherine Clarke4Sergio Federico Lombardo5Amanda Paul6Dorothy Hajdu7Carla Asorey Blázquez8Mayank Seth9Michelle Walton‐Clark10Luis Miguel Garcia Roldan11Rebecca Frances Geddes12Sophie Allison Conway13Katia Sánchez González14Paula García Domínguez15Sophie Keyte16Danica Pollard17Darren Kelly18Department of Internal Medicine Southern Counties Veterinary Specialists Ringwood Hampshire UKDepartment of Surgery Southern Counties Veterinary Specialists Ringwood Hampshire UKSouthern Counties Veterinary Specialists Ringwood Hampshire UKDavies Veterinary Specialists Higham Gobion Hertfordshire UKDavies Veterinary Specialists Higham Gobion Hertfordshire UKThe Ralph Veterinary Referral Centre Marlow UKHamilton Specialist Referrals Ltd High Wycombe Buckinghamshire UKLumbry Park Veterinary Specialists Alton Hampshire UKDick White Referrals Ltd Six Mile Bottom Cambridgeshire UKDick White Referrals Ltd Six Mile Bottom Cambridgeshire UKEastcott Veterinary Referrals Swindon UKEastcott Veterinary Referrals Swindon UKUniversity of London, Royal Veterinary College Department of Veterinary Clinical Sciences Hatfield UKUniversity of London, Royal Veterinary College Department of Veterinary Clinical Sciences Hatfield UKDick White Referrals Ltd Six Mile Bottom Cambridgeshire UKAnderson Moores Veterinary Specialists Winchester Hampshire UKLumbry Park Veterinary Specialists Alton Hampshire UKThe Roadhams Cambridgeshire Wisbech UKDepartment of Internal Medicine Southern Counties Veterinary Specialists Ringwood Hampshire UKABSTRACT Background Hypocalcemia is a relatively common complication after parathyroidectomy for treatment of primary hyperparathyroidism. Objectives To retrospectively evaluate clinical variables in dogs with primary hyperparathyroidism to determine whether or not an association exists between pre‐surgical variables and the development of post‐surgical hypocalcemia. Animals One hundred three dogs diagnosed with primary hyperparathyroidism and treated by parathyroidectomy in seven referral hospitals between 2010 and 2021. Material and Methods Data collected from medical records included signalment, physical examination findings, concurrent illnesses, ongoing medications, and clinicopathologic test results (including serum ALP activity, iCa, plasma phosphate and PTH concentrations). Dogs were assigned into groups based on lowest iCa post‐surgery: Group1 ≥ 1.1 mmol/L, Group2 < 1.1 mmol/L. The Mann–Whitney U test assessed associations between several variables of interest and the occurrence of post‐surgery hypocalcemia. ROC analyses were performed to identify variables that had the potential to predict the development of hypocalcemia after surgery. Results The median plasma PTH concentration pre‐surgery in dogs which developed hypocalcemia after surgery was significantly higher (232 pg/mL {[IQR] 108–421}) than in dogs which did not develop hypocalcemia after surgery (81.5 pg/mL {IQR 58.5–145.0}; p < 0.001). Plasma PTH concentration had a fair to good ability to predict the development of post‐surgery hypocalcemia, with AUC being 0.78 [95% confidence interval 0.67–0.89]. Using a cut‐off of ≥ 75 pg/mL, pre‐surgery plasma PTH concentration had a sensitivity of 96.6% and specificity of 42.3% for the development of post‐surgery hypocalcemia. Dogs that developed hypocalcemia after surgery were older and had lower body weights. Conclusion Pre‐surgery plasma PTH concentrations might be helpful in predicting those dogs at risk of developing hypocalcemia after parathyroidectomy.https://doi.org/10.1111/jvim.70016hypocalcemiaionized calciumprimary hyperparathyroidismPTH |
| spellingShingle | Victoria Travail Claudio Motta Charlotte Lea Andres Salas‐Garcia Katherine Clarke Sergio Federico Lombardo Amanda Paul Dorothy Hajdu Carla Asorey Blázquez Mayank Seth Michelle Walton‐Clark Luis Miguel Garcia Roldan Rebecca Frances Geddes Sophie Allison Conway Katia Sánchez González Paula García Domínguez Sophie Keyte Danica Pollard Darren Kelly Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy Journal of Veterinary Internal Medicine hypocalcemia ionized calcium primary hyperparathyroidism PTH |
| title | Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy |
| title_full | Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy |
| title_fullStr | Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy |
| title_full_unstemmed | Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy |
| title_short | Plasma Parathyroid Hormone Concentration as a Predictor of Post‐Operative Hypocalcemia in Dogs Diagnosed With Primary Hyperparathyroidism and Treated With Parathyroidectomy |
| title_sort | plasma parathyroid hormone concentration as a predictor of post operative hypocalcemia in dogs diagnosed with primary hyperparathyroidism and treated with parathyroidectomy |
| topic | hypocalcemia ionized calcium primary hyperparathyroidism PTH |
| url | https://doi.org/10.1111/jvim.70016 |
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