A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis.

A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis.

Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice, similar to the embryonic lethal phenotype of the Gata1 gene knockout. Ho...

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Main Authors: Ioannis-Marios Roussis, David J Pearton, Umar Niazi, Grigorios Tsaknakis, Giorgio L Papadopoulos, Riley Cook, Mansoor Saqi, Jiannis Ragoussis, John Strouboulis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011617
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