Role of toll-like receptor 4 in skeletal muscle damage in chronic limb-threatening ischemia

Role of toll-like receptor 4 in skeletal muscle damage in chronic limb-threatening ischemia

Objective: Toll-like receptors (TLRs) are key pattern recognition receptors in the innate immune system. In particular, the TLR4-mediated immune response has been implicated in ischemia-induced tissue injury. Mounting evidence supports a detrimental role of the innate immune system in the pathophysi...

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Main Authors: Ali Navi, PhD, FRCS, Hemanshu Patel, MRCS, Xu Shiwen, PhD, Daryll Baker, PhD, FRCS, David Abraham, PhD, Janice Tsui, MD, FRCS
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:JVS - Vascular Science
Subjects:
Critical limb-threatening ischemia (CLTI)
Inflammation
Peripheral arterial disease (PAD)
Skeletal muscle
Toll-like receptor (TLR)
Online Access:http://www.sciencedirect.com/science/article/pii/S2666350324000051
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