Development and validation of a LC-MS/MS method for the simultaneous determination of simnotrelvir and ritonavir in human serum and bronchoalveolar lavage fluid

Development and validation of a LC-MS/MS method for the simultaneous determination of simnotrelvir and ritonavir in human serum and bronchoalveolar lavage fluid

Abstract “Xiannuoxin” (simnotrelvir/ritonavir) is a novel anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug developed in China, which plays an antiviral role by inhibiting 3C-like protease (3CLpro). At present, it has been put into clinical use, while a simple, accurate and sens...

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Main Authors: Xiaoyu Yang, Wanling Lin, Yushang Zhao, Chaoyue Zhao, Fei Zhou, Dong Wang, Zhihong Yue, Lin Pei, Mei Jia, Bin Cao, Lin-Lin Cao, Hui Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Chemistry
Subjects:
LC-MS/MS
Simnotrelvir
Ritonavir
Urea
Serum
Bronchoalveolar lavage fluid
Online Access:https://doi.org/10.1186/s13065-025-01534-x
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https://doi.org/10.1186/s13065-025-01534-x

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