A randomized trial to evaluate the pharmacokinetics, pharmacodynamics, and safety of vadadustat in patients with anemia associated with chronic kidney disease receiving hemodialysis

Abstract Background Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor for treatment of anemia in dialysis-dependent chronic kidney disease (CKD) with a starting dose of 300 mg once daily (dose adjustments up to 600 mg). A recent phase 1b study evaluated the pharmacokinetics...

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Bibliographic Details
Main Authors: Pamela Navarro-Gonzales, Ajit Chavan, Don Wang, Steven K. Burke, Kevin Dykstra
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Nephrology
Subjects:
Online Access:https://doi.org/10.1186/s12882-025-04367-x
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