A stimulus‐contingent positive feedback loop enables IFN‐β dose‐dependent activation of pro‐inflammatory genes

A stimulus‐contingent positive feedback loop enables IFN‐β dose‐dependent activation of pro‐inflammatory genes

Abstract Type I interferons (IFN) induce powerful antiviral and innate immune responses via the transcription factor, IFN‐stimulated gene factor (ISGF3). However, in some pathological contexts, type I IFNs are responsible for exacerbating inflammation. Here, we show that a high dose of IFN‐β also ac...

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Bibliographic Details
Main Authors: Catera L Wilder, Diane Lefaudeux, Raisa Mathenge, Kensei Kishimoto, Alma Zuniga Munoz, Minh A Nguyen, Aaron S Meyer, Quen J Cheng, Alexander Hoffmann
Format: Article
Language:English
Published: Springer Nature 2023-03-01
Series:Molecular Systems Biology
Subjects:
IFN‐β
inflammatory response
ISGF3
signaling dynamics
stimulus‐contingent positive feedback loop
Online Access:https://doi.org/10.15252/msb.202211294
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https://doi.org/10.15252/msb.202211294

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