Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform
Abstract Previously, a synchrotron‐based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Precision Radiation Oncology |
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| Online Access: | https://doi.org/10.1002/pro6.1243 |
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| author | Fada Guan Dadi Jiang Xiaochun Wang Ming Yang Kiminori Iga Yuting Li Lawrence Bronk Julianna Bronk Liang Wang Youming Guo Narayan Sahoo David R. Grosshans Albert C. Koong Xiaorong R. Zhu Radhe Mohan |
| author_facet | Fada Guan Dadi Jiang Xiaochun Wang Ming Yang Kiminori Iga Yuting Li Lawrence Bronk Julianna Bronk Liang Wang Youming Guo Narayan Sahoo David R. Grosshans Albert C. Koong Xiaorong R. Zhu Radhe Mohan |
| author_sort | Fada Guan |
| collection | DOAJ |
| description | Abstract Previously, a synchrotron‐based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a custom robotic motion platform to automatically shift the positions of biological samples. The beam was first broadened with a thin tungsten scatterer and shaped by customized brass collimators for irradiating cell/organoid cultures in 96‐well plates (a 7‐mm‐diameter circle) or for irradiating mice (1‐cm2 square). Motion patterns of the robotic platform were written in G‐code, with 9‐mm spot spacing used for the 96‐well plates and 10.6‐mm spacing for the mice. The accuracy of target positioning was verified with a self‐leveling laser system. The dose delivered in the experimental conditions was validated with EBT‐XD film attached to the 96‐well plate or the back of the mouse. Our film‐measured dose profiles matched Monte Carlo calculations well (1D gamma pass rate >95% with the criteria of 2%/1 mm/2% dose threshold). The FLASH dose rates were 113.7 Gy/s for cell/organoid irradiation and 191.3 Gy/s for mouse irradiation. These promising results indicate that this robotic platform can be used to effectively increase the field size for preclinical experiments with proton FLASH. |
| format | Article |
| id | doaj-art-a48a80b14f364c6dbe9f3cdea67c4006 |
| institution | Kabale University |
| issn | 2398-7324 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Radiation Oncology |
| spelling | doaj-art-a48a80b14f364c6dbe9f3cdea67c40062024-12-26T13:26:47ZengWileyPrecision Radiation Oncology2398-73242024-12-018416818110.1002/pro6.1243Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platformFada Guan0Dadi Jiang1Xiaochun Wang2Ming Yang3Kiminori Iga4Yuting Li5Lawrence Bronk6Julianna Bronk7Liang Wang8Youming Guo9Narayan Sahoo10David R. Grosshans11Albert C. Koong12Xiaorong R. Zhu13Radhe Mohan14Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USAAbstract Previously, a synchrotron‐based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a custom robotic motion platform to automatically shift the positions of biological samples. The beam was first broadened with a thin tungsten scatterer and shaped by customized brass collimators for irradiating cell/organoid cultures in 96‐well plates (a 7‐mm‐diameter circle) or for irradiating mice (1‐cm2 square). Motion patterns of the robotic platform were written in G‐code, with 9‐mm spot spacing used for the 96‐well plates and 10.6‐mm spacing for the mice. The accuracy of target positioning was verified with a self‐leveling laser system. The dose delivered in the experimental conditions was validated with EBT‐XD film attached to the 96‐well plate or the back of the mouse. Our film‐measured dose profiles matched Monte Carlo calculations well (1D gamma pass rate >95% with the criteria of 2%/1 mm/2% dose threshold). The FLASH dose rates were 113.7 Gy/s for cell/organoid irradiation and 191.3 Gy/s for mouse irradiation. These promising results indicate that this robotic platform can be used to effectively increase the field size for preclinical experiments with proton FLASH.https://doi.org/10.1002/pro6.1243proton therapyultra‐high dose rate FLASHrobotic motion technique |
| spellingShingle | Fada Guan Dadi Jiang Xiaochun Wang Ming Yang Kiminori Iga Yuting Li Lawrence Bronk Julianna Bronk Liang Wang Youming Guo Narayan Sahoo David R. Grosshans Albert C. Koong Xiaorong R. Zhu Radhe Mohan Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform Precision Radiation Oncology proton therapy ultra‐high dose rate FLASH robotic motion technique |
| title | Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform |
| title_full | Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform |
| title_fullStr | Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform |
| title_full_unstemmed | Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform |
| title_short | Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform |
| title_sort | mimicking large spot scanning radiation fields for proton flash preclinical studies with a robotic motion platform |
| topic | proton therapy ultra‐high dose rate FLASH robotic motion technique |
| url | https://doi.org/10.1002/pro6.1243 |
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