S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory

S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory

Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) and nitric oxide (NO) both play vital roles in learning and memory; however, the underlying mechanisms connecting them have remained elusive. To address this question, our study surprisingly observed that during learning and memory tasks, S-nit...

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Bibliographic Details
Main Authors: Boyu Chu, Xinhua Qiao, Hui Ye, Xiaoli Cui, Shuli Zhang, Wenting Su, Yuying Zhang, Chuanxin Sun, Xuanhao Wu, Tiepeng Wang, Hua Li, Jianbing Wu, Zhangjian Huang, Chang Chen
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Redox Biology
Subjects:
CaMKIIα
S-nitrosation/S-nitrosylation
Learning and memory
Age-related cognitive impairment
Response capacity
Presynaptic release probability
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002976
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