Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation
Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium breve strain (CCFM1025) were assessed in sleep-deprived mice....
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-07-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250162 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550208422379520 |
|---|---|
| author | Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen |
| author_facet | Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen |
| author_sort | Peijun Tian |
| collection | DOAJ |
| description | Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium breve strain (CCFM1025) were assessed in sleep-deprived mice. CCFM1025 improved the body weight and food and water intake of the mice. It also alleviated SD-induced cognitive behavioural abnormalities (in the novel object recognition test), but did not show beneficial effects on mood- and spatial memory-related behaviours. CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified, such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. Those metabolites may participate in gut-brain communication by acting on the striatal melatonin system, for example to increase melatonin levels, and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1. Collectively, administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites. These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies. |
| format | Article |
| id | doaj-art-a3dad572f27646a682b748f6be938a65 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a3dad572f27646a682b748f6be938a652025-01-10T06:56:47ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-07-011341951196110.26599/FSHW.2022.9250162Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivationPeijun Tian0Yunfei Hou1Zheng Wang2Jiaona Jiang3Xin Qian4Zhihao Qu5Jianxin Zhao6Gang Wang7Wei Chen8State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaGut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium breve strain (CCFM1025) were assessed in sleep-deprived mice. CCFM1025 improved the body weight and food and water intake of the mice. It also alleviated SD-induced cognitive behavioural abnormalities (in the novel object recognition test), but did not show beneficial effects on mood- and spatial memory-related behaviours. CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified, such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. Those metabolites may participate in gut-brain communication by acting on the striatal melatonin system, for example to increase melatonin levels, and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1. Collectively, administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites. These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.https://www.sciopen.com/article/10.26599/FSHW.2022.9250162bifidobacteriumsleepcircadian rhythmpurinegut microbiome |
| spellingShingle | Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation Food Science and Human Wellness bifidobacterium sleep circadian rhythm purine gut microbiome |
| title | Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation |
| title_full | Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation |
| title_fullStr | Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation |
| title_full_unstemmed | Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation |
| title_short | Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation |
| title_sort | probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation |
| topic | bifidobacterium sleep circadian rhythm purine gut microbiome |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250162 |
| work_keys_str_mv | AT peijuntian probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT yunfeihou probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT zhengwang probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT jiaonajiang probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT xinqian probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT zhihaoqu probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT jianxinzhao probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT gangwang probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation AT weichen probioticsadministrationalleviatescognitiveimpairmentandcircadianrhythmdisturbanceinducedbysleepdeprivation |