Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer

Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer

Abstract Pregnancy is associated with a transient increase in risk for breast cancer. However, the mechanism underlying pregnancy‐associated breast cancer (PABC) is poorly understood. Here, we identify the protease pappalysin‐1 (PAPP‐A) as a pregnancy‐dependent oncogene. Transgenic expression of PAP...

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Bibliographic Details
Main Authors: Yukie Takabatake, Claus Oxvig, Chandandeep Nagi, Kerin Adelson, Shabnam Jaffer, Hank Schmidt, Patricia J Keely, Kevin W Eliceiri, John Mandeli, Doris Germain
Format: Article
Language:English
Published: Springer Nature 2016-03-01
Series:EMBO Molecular Medicine
Subjects:
breastfeeding
IGF‐binding protein 4 and 5
insulin‐like growth (IGF) factor signaling
involution
Online Access:https://doi.org/10.15252/emmm.201606273
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https://doi.org/10.15252/emmm.201606273

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