PHD1 regulates p53‐mediated colorectal cancer chemoresistance

PHD1 regulates p53‐mediated colorectal cancer chemoresistance

Abstract Overcoming resistance to chemotherapy is a major challenge in colorectal cancer (CRC) treatment, especially since the underlying molecular mechanisms remain unclear. We show that silencing of the prolyl hydroxylase domain protein PHD1, but not PHD2 or PHD3, prevents p53 activation upon chem...

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Bibliographic Details
Main Authors: Sofie Deschoemaeker, Giusy Di Conza, Sergio Lilla, Rosa Martín‐Pérez, Daniela Mennerich, Lise Boon, Stefanie Hendrikx, Oliver DK Maddocks, Christian Marx, Praveen Radhakrishnan, Hans Prenen, Martin Schneider, Johanna Myllyharju, Thomas Kietzmann, Karen H Vousden, Sara Zanivan, Massimiliano Mazzone
Format: Article
Language:English
Published: Springer Nature 2015-08-01
Series:EMBO Molecular Medicine
Subjects:
chemotherapy resistance
colorectal cancer
DNA repair
prolyl hydroxylase domain proteins
tumor suppressor p53
Online Access:https://doi.org/10.15252/emmm.201505492
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