Production of Oncolytic Measles Virus in Vero Cells: Impact of Culture Medium and Multiplicity of Infection

Production of Oncolytic Measles Virus in Vero Cells: Impact of Culture Medium and Multiplicity of Infection

Oncolytic measles virus (MeV) is a promising anti-cancer treatment. However, the production of high titers of infectious MeV (typically 10<sup>7</sup>–10<sup>9</sup> TCID<sub>50</sub> per dose) is challenging because the virus is unstable under typical production...

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Bibliographic Details
Main Authors: Dustin Eckhardt, Jana Mueller, Jonas Friedrich, Jan-P. Klee, Irakli Sardlishvili, Lars E. Walter, Stefanie Fey, Peter Czermak, Denise Salzig
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
multiplicity of infection (MOI)
media adaption
chemically defined medium (CDM)
serum-free medium (SFM)
viral vaccines
vectors
Online Access:https://www.mdpi.com/1999-4915/16/11/1740
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