Integrative bioinformatics and deep learning to identify common genetic pathways in Crohn’s disease and ischemic cardiomyopathy

Integrative bioinformatics and deep learning to identify common genetic pathways in Crohn’s disease and ischemic cardiomyopathy

Crohn’s disease (CD) and ischemic cardiomyopathy (ICM) share inflammatory characteristics, yet their common genetic underpinnings remain underexplored. Using an integrative bioinformatics approach, we analyzed GEO datasets (GSE3365 and GSE9128) to identify shared genetic pathways between CD and ICM....

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Bibliographic Details
Main Authors: Reza Maddah, Zahra Sadat Aghili, Fahimeh Ghanbari, Amirhossein Hajialiasgary Najafabadi, Sedigheh Asgary
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
AutoClass, bioinformatics
Crohn’s disease
Deep learning
Genetic pathways
Hub genes
Inflammatory mechanisms
Online Access:http://www.sciencedirect.com/science/article/pii/S1687157X25000733
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