High-intensity helical flow: a double-edged sword in coronary artery haemodynamics
The role of helical flow in human coronary arteries remains uncertain, yet its understanding promises unprecedented insights into atherosclerotic processes. In this study, we investigated the effects of helical flow and key haemodynamic descriptors in 39 patient-specific left coronary artery trees o...
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The Royal Society
2025-08-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.242184 |
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| author | Chi Shen Mingzi Zhang Hamed Keramati Diogo Ferreira de Almeida Susann Beier |
| author_facet | Chi Shen Mingzi Zhang Hamed Keramati Diogo Ferreira de Almeida Susann Beier |
| author_sort | Chi Shen |
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| description | The role of helical flow in human coronary arteries remains uncertain, yet its understanding promises unprecedented insights into atherosclerotic processes. In this study, we investigated the effects of helical flow and key haemodynamic descriptors in 39 patient-specific left coronary artery trees of the Automated Segmentation of Coronary Arteries (ASOCA) dataset: 20 non-stenosed and 19 stenosed. Absolute helical flow intensity h2 correlated with higher time-averaged endothelial shear stress in all vessel segments regardless of stenoses ([Formula: see text]). In stenosed cases, this correlation was so prominent that the vessel area exposed to adversely low time-averaged endothelial shear stress reduced (less than 0.5 Pa[Formula: see text]), and simultaneously, areas of adversely high time-averaged endothelial shear stress increased (greater than 4.71 Pa, [Formula: see text]) coinciding with high h2 regions. This suggests that helical flow in coronaries is not always protective, as previously thought, because it not only mitigates low time-averaged endothelial shear stress associated with long-term plaque development and restenosis but also exacerbates adversely high time-averaged endothelial shear stress linked to increased plaque vulnerability and even acute events. Our findings redefined the current understanding of the role of helical blood flow in cardiovascular atherosclerotic disease processes. |
| format | Article |
| id | doaj-art-a34b44d8e14f4b9598c6de0cb7ee8a1f |
| institution | Kabale University |
| issn | 2054-5703 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | The Royal Society |
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| series | Royal Society Open Science |
| spelling | doaj-art-a34b44d8e14f4b9598c6de0cb7ee8a1f2025-08-20T04:02:12ZengThe Royal SocietyRoyal Society Open Science2054-57032025-08-0112810.1098/rsos.242184High-intensity helical flow: a double-edged sword in coronary artery haemodynamicsChi Shen0Mingzi Zhang1Hamed Keramati2Diogo Ferreira de Almeida3Susann Beier4School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales, AustraliaSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales, AustraliaSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales, AustraliaVirtonomy GmbH, Munich, GermanySchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales, AustraliaThe role of helical flow in human coronary arteries remains uncertain, yet its understanding promises unprecedented insights into atherosclerotic processes. In this study, we investigated the effects of helical flow and key haemodynamic descriptors in 39 patient-specific left coronary artery trees of the Automated Segmentation of Coronary Arteries (ASOCA) dataset: 20 non-stenosed and 19 stenosed. Absolute helical flow intensity h2 correlated with higher time-averaged endothelial shear stress in all vessel segments regardless of stenoses ([Formula: see text]). In stenosed cases, this correlation was so prominent that the vessel area exposed to adversely low time-averaged endothelial shear stress reduced (less than 0.5 Pa[Formula: see text]), and simultaneously, areas of adversely high time-averaged endothelial shear stress increased (greater than 4.71 Pa, [Formula: see text]) coinciding with high h2 regions. This suggests that helical flow in coronaries is not always protective, as previously thought, because it not only mitigates low time-averaged endothelial shear stress associated with long-term plaque development and restenosis but also exacerbates adversely high time-averaged endothelial shear stress linked to increased plaque vulnerability and even acute events. Our findings redefined the current understanding of the role of helical blood flow in cardiovascular atherosclerotic disease processes.https://royalsocietypublishing.org/doi/10.1098/rsos.242184coronary artery diseasehaemodynamicscomputational fluid dynamics |
| spellingShingle | Chi Shen Mingzi Zhang Hamed Keramati Diogo Ferreira de Almeida Susann Beier High-intensity helical flow: a double-edged sword in coronary artery haemodynamics Royal Society Open Science coronary artery disease haemodynamics computational fluid dynamics |
| title | High-intensity helical flow: a double-edged sword in coronary artery haemodynamics |
| title_full | High-intensity helical flow: a double-edged sword in coronary artery haemodynamics |
| title_fullStr | High-intensity helical flow: a double-edged sword in coronary artery haemodynamics |
| title_full_unstemmed | High-intensity helical flow: a double-edged sword in coronary artery haemodynamics |
| title_short | High-intensity helical flow: a double-edged sword in coronary artery haemodynamics |
| title_sort | high intensity helical flow a double edged sword in coronary artery haemodynamics |
| topic | coronary artery disease haemodynamics computational fluid dynamics |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.242184 |
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