Small Molecule Inhibitor of Protein Kinase C DeltaI (PKCδI) Decreases Inflammatory Pathways and Gene Expression and Improves Metabolic Function in Diet-Induced Obese Mouse Model

Small Molecule Inhibitor of Protein Kinase C DeltaI (PKCδI) Decreases Inflammatory Pathways and Gene Expression and Improves Metabolic Function in Diet-Induced Obese Mouse Model

Obesity promotes metabolic diseases such as type 2 diabetes and cardiovascular disease. PKCδI is a serine/threonine kinase which regulates cell growth, differentiation, and survival. Caspase-3 cleavage of PKCδI releases the C-terminal catalytic fragment (PKCδI_C), which promotes inflammation and apo...

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Bibliographic Details
Main Authors: Brenna Osborne, Rekha S. Patel, Meredith Krause-Hauch, Ashley Lui, Gitanjali Vidyarthi, Niketa A. Patel
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biology
Subjects:
PKCδI
catalytic fragment
adipose tissue
DIO mice
inflammation
TNFα
Online Access:https://www.mdpi.com/2079-7737/13/11/943
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