Exploring individual differences in fear extinction in male and female mice: insights from HPA axis, microbiota, and transcriptomics

Abstract Exposure to traumatic life events may compromise physical and mental health of specific subjects. While some individuals extinguish fear appropriately, others exhibit an inefficient and persistent fear response, with remarkable differences between sexes. Understanding the heterogeneity in f...

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Bibliographic Details
Main Authors: Marc Ten-Blanco, María Ponce-Renilla, Inmaculada Pereda-Pérez, Cristina Izquierdo-Luengo, Carlo Bressa, Olga Zafra, Rosa María Tolón, Fernando Berrendero
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03400-9
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