A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis

A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis

Abstract Hyperhomocysteinemia (HHy) can lead to vascular endothelial cell dysfunction, progressive inflammation and lipid metabolism disorder, which finally result in the onset and development of atherosclerosis, a major contributor to cardiovascular diseases. Given the complexity of pathological pr...

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Bibliographic Details
Main Authors: Qi Zhang, Shengchao Ma, Xue Kang, Yi Liu, Fei Ma, Feifei Yu, Xiaolan Luo, Guizhong Li, Yinju Hao, Huiping Zhang, Bin Liu, Yideng Jiang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Atherosclerosis
Shikonin
Evolocumab
Endothelial cells dysfunction
Cholesterol flow homeostasis
Online Access:https://doi.org/10.1186/s12951-025-03436-5
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https://doi.org/10.1186/s12951-025-03436-5

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