Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study
BackgroundAbdominal aortic aneurysm (AAA) is one of the most dangerous types of vascular diseases worldwide. Metabolic disturbance affects disease risk and provide underlying therapeutic targets. Previous studies have reported an association between metabolic disorders and AAA. However, evidence of...
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Frontiers Media S.A.
2025-01-01
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| author | Qian Guo Xinghua Xu Xiaohui Li Yang Mao Shengqiang Li Yuxin Yao Xiang Li Yaxing Li Jiayue Feng Yan Shu Xingli Xu |
| author_facet | Qian Guo Xinghua Xu Xiaohui Li Yang Mao Shengqiang Li Yuxin Yao Xiang Li Yaxing Li Jiayue Feng Yan Shu Xingli Xu |
| author_sort | Qian Guo |
| collection | DOAJ |
| description | BackgroundAbdominal aortic aneurysm (AAA) is one of the most dangerous types of vascular diseases worldwide. Metabolic disturbance affects disease risk and provide underlying therapeutic targets. Previous studies have reported an association between metabolic disorders and AAA. However, evidence of a causal relationship between blood metabolites and AAA is still lacking at present.MethodsUsing Mendelian randomization (MR), we assessed the causal association between 1,400 serum metabolites and AAA. The inverse variance weighted method (IVW), weighted median, MR-Egger regression, simple mode, as well as weighted mode methods were used for evaluating the causality between blood metabolites and AAA. Pleiotropy and heterogeneity tests were further conducted.ResultsThrough strict screening, 17 known metabolites, 7 unknown metabolites and 5 metabolite ratios related to AAA were identified. Among all the metabolites, 24 were found to have negative associations, while 5 exhibited positive associations. The top five metabolites associated with an increased risk of AAA were Oleoyl-linoleoyl-glycerol (18:1/18:2) [2], Glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)), Glycochenodeoxycholate 3-sulfate, X-21441 and X-24328. In contrast, the top five metabolites that were linked to a reduced risk of AAA included Uridine to pseudouridine ratio, Octadecanedioate, Phosphate to oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] ratio, 1-(1-enyl-palmitoyl)-GPE (p-16:0), and 1-stearoyl-GPG (18:0).ConclusionAmong the 1,400 blood metabolites, we identified 17 known metabolites, 7 unknown metabolites, and 5 metabolite ratios associated with AAA. This MR study may provide a novel significant insight for the screening and prevention of AAA. |
| format | Article |
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| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-a247acccf0264da597c2926c01b1c7e12025-01-03T06:46:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15142931514293Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization studyQian Guo0Xinghua Xu1Xiaohui Li2Yang Mao3Shengqiang Li4Yuxin Yao5Xiang Li6Yaxing Li7Jiayue Feng8Yan Shu9Xingli Xu10Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Cardiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiology, State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, ChinaBackgroundAbdominal aortic aneurysm (AAA) is one of the most dangerous types of vascular diseases worldwide. Metabolic disturbance affects disease risk and provide underlying therapeutic targets. Previous studies have reported an association between metabolic disorders and AAA. However, evidence of a causal relationship between blood metabolites and AAA is still lacking at present.MethodsUsing Mendelian randomization (MR), we assessed the causal association between 1,400 serum metabolites and AAA. The inverse variance weighted method (IVW), weighted median, MR-Egger regression, simple mode, as well as weighted mode methods were used for evaluating the causality between blood metabolites and AAA. Pleiotropy and heterogeneity tests were further conducted.ResultsThrough strict screening, 17 known metabolites, 7 unknown metabolites and 5 metabolite ratios related to AAA were identified. Among all the metabolites, 24 were found to have negative associations, while 5 exhibited positive associations. The top five metabolites associated with an increased risk of AAA were Oleoyl-linoleoyl-glycerol (18:1/18:2) [2], Glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)), Glycochenodeoxycholate 3-sulfate, X-21441 and X-24328. In contrast, the top five metabolites that were linked to a reduced risk of AAA included Uridine to pseudouridine ratio, Octadecanedioate, Phosphate to oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] ratio, 1-(1-enyl-palmitoyl)-GPE (p-16:0), and 1-stearoyl-GPG (18:0).ConclusionAmong the 1,400 blood metabolites, we identified 17 known metabolites, 7 unknown metabolites, and 5 metabolite ratios associated with AAA. This MR study may provide a novel significant insight for the screening and prevention of AAA.https://www.frontiersin.org/articles/10.3389/fphar.2024.1514293/fullMendelian randomization studyabdominal aortic aneurysmmetabolitesmetabolite ratiosmetabolomics |
| spellingShingle | Qian Guo Xinghua Xu Xiaohui Li Yang Mao Shengqiang Li Yuxin Yao Xiang Li Yaxing Li Jiayue Feng Yan Shu Xingli Xu Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study Frontiers in Pharmacology Mendelian randomization study abdominal aortic aneurysm metabolites metabolite ratios metabolomics |
| title | Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study |
| title_full | Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study |
| title_fullStr | Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study |
| title_full_unstemmed | Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study |
| title_short | Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study |
| title_sort | assessing the relationships of 1 400 blood metabolites with abdominal aortic aneurysm a mendelian randomization study |
| topic | Mendelian randomization study abdominal aortic aneurysm metabolites metabolite ratios metabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1514293/full |
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