Unveiling the pathogenic mechanisms of polyethylene terephthalate-microplastic-driven osteoarthritis and rheumatoid arthritis: PTGS2 signaling hub-oriented toxicity profiling

Unveiling the pathogenic mechanisms of polyethylene terephthalate-microplastic-driven osteoarthritis and rheumatoid arthritis: PTGS2 signaling hub-oriented toxicity profiling

In recent years, health problems caused by microplastics (MPs) have attracted much attention. The pathogenic mechanisms of them in osteoarthritis (OA) and rheumatoid arthritis (RA) are still unclear and urgently need in-depth exploration. The targets related to OA and RA of Polyethylene Terephthalat...

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Bibliographic Details
Main Authors: Jingkai Di, Shuang Wang, Lujia Liu, Keying Rong, Zijian Guo, Yingda Qin, Feida Wang, Chuan Xiang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Microplastics
Osteoarthritis
Rheumatoid arthritis
Network toxicology
Molecular docking
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325011613
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