Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis
Abstract Utilizing ultrathin 2D metal–organic framework nanosheets (2D MONs) as supports for incorporating chiral catalysts represents a highly promising avenue in the field of asymmetric catalysis. In this study, four pairs of isostructural chiral metal–organic layers (MOLs) adorned with N‐Heterocy...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202412592 |
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| author | Xinchao Wang Zhiwen Wang Zhaoxing Wang Tian‐Fu Liu Shangda Li Fei Wang Jian Zhang |
| author_facet | Xinchao Wang Zhiwen Wang Zhaoxing Wang Tian‐Fu Liu Shangda Li Fei Wang Jian Zhang |
| author_sort | Xinchao Wang |
| collection | DOAJ |
| description | Abstract Utilizing ultrathin 2D metal–organic framework nanosheets (2D MONs) as supports for incorporating chiral catalysts represents a highly promising avenue in the field of asymmetric catalysis. In this study, four pairs of isostructural chiral metal–organic layers (MOLs) adorned with N‐Heterocyclic carbene (NHC) groups are successfully synthesized. Notably, the obtained bulky (S)‐1‐Zn crystals can be readily delaminated into ultrathin MONs consisting of 1–2 layers through an ion intercalation‐assisted exfoliation process. Subsequent asymmetric catalysis studies revealed that the NHC sites can be effectively activated by a proton sponge while maintaining structural integrity for the subsequent benzoin condensation. Due to their well‐exposed catalytic sites, ultrathin morphology, and porous structure, the (S)‐1‐Zn nanosheets exhibited significantly enhanced yield and enantioselectivity compared to their bulk counterparts and organic precursors. This research highlights an efficient strategy for incorporating chiral NHC species onto 2D MONs, thereby unlocking their immense potential for heterogeneous asymmetric catalysis. |
| format | Article |
| id | doaj-art-a21bd7d0a95143efb8f3c46f1c1c38b7 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-a21bd7d0a95143efb8f3c46f1c1c38b72025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.202412592Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric CatalysisXinchao Wang0Zhiwen Wang1Zhaoxing Wang2Tian‐Fu Liu3Shangda Li4Fei Wang5Jian Zhang6State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. ChinaAbstract Utilizing ultrathin 2D metal–organic framework nanosheets (2D MONs) as supports for incorporating chiral catalysts represents a highly promising avenue in the field of asymmetric catalysis. In this study, four pairs of isostructural chiral metal–organic layers (MOLs) adorned with N‐Heterocyclic carbene (NHC) groups are successfully synthesized. Notably, the obtained bulky (S)‐1‐Zn crystals can be readily delaminated into ultrathin MONs consisting of 1–2 layers through an ion intercalation‐assisted exfoliation process. Subsequent asymmetric catalysis studies revealed that the NHC sites can be effectively activated by a proton sponge while maintaining structural integrity for the subsequent benzoin condensation. Due to their well‐exposed catalytic sites, ultrathin morphology, and porous structure, the (S)‐1‐Zn nanosheets exhibited significantly enhanced yield and enantioselectivity compared to their bulk counterparts and organic precursors. This research highlights an efficient strategy for incorporating chiral NHC species onto 2D MONs, thereby unlocking their immense potential for heterogeneous asymmetric catalysis.https://doi.org/10.1002/advs.202412592asymmetric catalysisbenzoin condensationchiral N‐Heterocyclic carbenesheterogeneous catalysismetal−organic framework nanosheets |
| spellingShingle | Xinchao Wang Zhiwen Wang Zhaoxing Wang Tian‐Fu Liu Shangda Li Fei Wang Jian Zhang Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis Advanced Science asymmetric catalysis benzoin condensation chiral N‐Heterocyclic carbenes heterogeneous catalysis metal−organic framework nanosheets |
| title | Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis |
| title_full | Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis |
| title_fullStr | Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis |
| title_full_unstemmed | Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis |
| title_short | Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis |
| title_sort | synthesis of homochiral n heterocyclic carbene based nanosheets for enhanced asymmetric catalysis |
| topic | asymmetric catalysis benzoin condensation chiral N‐Heterocyclic carbenes heterogeneous catalysis metal−organic framework nanosheets |
| url | https://doi.org/10.1002/advs.202412592 |
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