Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling

Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling

The endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) modulates inflammatory and neuroinflammatory signaling through toll-like receptors (TLRs) in human and mouse macrophages, human blood cells and alcohol-preferring (P) rat brains. Although it is recognized that 3α,5α-THP inhibits...

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Bibliographic Details
Main Authors: Alejandro G. Lopez, Venkat R. Chirasani, Irina Balan, Todd K. O’Buckley, Makayla R. Adelman, A. Leslie Morrow
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
allopregnanolone
inflammation
toll-like receptor activation
TIRAP
lipid A
Online Access:https://www.mdpi.com/2218-273X/14/11/1441
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