Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Abstract The continuing emergence of immune evasive SARS-CoV-2 variants and the previous SARS-CoV-1 outbreak collectively underscore the need for broadly protective sarbecovirus vaccines. Targeting the conserved S2 subunit of SARS-CoV-2 is a particularly promising approach to elicit broad protection...

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Bibliographic Details
Main Authors: Peter J. Halfmann, Raj S. Patel, Kathryn Loeffler, Atsuhiro Yasuhara, Lee-Ann Van De Velde, Jie E. Yang, Jordan Chervin, Chloe Troxell, Min Huang, Naiying Zheng, Elizabeth R. Wright, Paul G. Thomas, Patrick C. Wilson, Yoshihiro Kawaoka, Ravi S. Kane
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55824-y
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