IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving inflammation in male mice

IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving inflammation in male mice

Abstract During the resolution of inflammation, Ly6C+F4/80- monocytes differentiate to Ly6C-F4/80+ macrophages that exert apoptotic cell engulfment (efferocytosis) properties and consequently convert to interferon (IFN)-β-producing macrophages. Here, we report that exposure to IFN-β, or transforming...

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Main Authors: Orly Zeituni-Timor, Soaad Soboh, Ahmad Zaid, Hiba Yaseen, Senthil Kumaran Satyanarayanan, Maha Abu Zeid, Esther Silberberg, Priya Goswami, Sagie Schif-Zuck, Sarit Larisch, Amiram Ariel
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08707-3
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https://doi.org/10.1038/s42003-025-08707-3

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