Gene Expression Profiling in Organ Transplantation
Aim of Review. Huge effort is being made among the transplant community investigating novel biomarkers that enable transplant clinicians to identify patients at risk for allograft rejection or those who will develop tolerance so that immunosuppression could be safely minimized or even ideally withd...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/180201 |
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| Summary: | Aim of Review.
Huge effort is being made among the transplant community investigating novel
biomarkers that enable transplant clinicians to identify patients at risk for allograft
rejection or those who will develop tolerance so that immunosuppression could be
safely minimized or even ideally withdrawn.
Despite the important advances achieved in the identification of several potential
biomarkers of tolerance, rejection, or both, validation and demonstration of their clinical
utility still needs to be tested, which will need international cooperative networks.
It is important to note that the reproducibility of differently expressed genes might be
affected by many factors such as gene ranking and selection methods, inherent
differences between types, and the choice of thresholds. However, because microarray
analyses are expensive and time consuming and their statistical evaluation is often very
difficult, gene expression analysis using the RTPCR method is nowadays
recommended.
Conclusions.
In the field of organ transplantation, gene-expression-based decision might help in
improving patient and graft outcome and there are a multitude of studies showing that
gene-expression profiling is feasible. |
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| ISSN: | 2090-214X 2090-2158 |