Significance of Gelsolin Superfamily Genes in Diagnosis, Prognosis and Immune Microenvironment Regulation for Endometrial Cancer

Significance of Gelsolin Superfamily Genes in Diagnosis, Prognosis and Immune Microenvironment Regulation for Endometrial Cancer

ABSTRACT Background Previously, anti‐CTLA4 and anti‐PD‐1/PD‐L1 immunotherapies have shown limited efficacy in MSI‐H/MMR‐D endometrial cancer, leading to poor clinical outcomes. The gelsolin superfamily, which includes GSN, SCIN, VILL, VIL1, CAPG, AVIL, SVIL, and FLII, plays crucial roles in cell mot...

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Main Authors: Senwei Jiang, Minjuan Ye, Jing Wan, Qingjian Ye, Suli Qiu, Yuebo Yang, Xiaomao Li
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Cancer Medicine
Subjects:
endometrial cancer
gelsolin superfamily
immune infiltration
immunosuppressive tumor microenvironment
immunotherapy
Online Access:https://doi.org/10.1002/cam4.70584
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https://doi.org/10.1002/cam4.70584

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