Effects of estrogen and mechanical loading on cultured cells derived from mandibular condylar cartilage

Effects of estrogen and mechanical loading on cultured cells derived from mandibular condylar cartilage

Abstract Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative condition influenced by mechanical loading and hormonal factors, particularly estrogen. Despite its established role in TMJ pathophysiology, the mechanisms underlying the effects of estrogen on joint cartilage remain unclear,...

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Bibliographic Details
Main Authors: Jin Tsuchida, Yuya Nakao, Koken Sato, Osamu Uehara, Itaru Mizoguchi, Yoshihiro Abiko, Masahiro Iijima
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Temporomandibular joint osteoarthritis
Mandibular condylar cartilage
Estrogen
Mechanical loading
Extracellular matrix
Online Access:https://doi.org/10.1038/s41598-025-07770-4
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https://doi.org/10.1038/s41598-025-07770-4

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