Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms
Abstract Prostate cancer (PCa) is one of the most prevalent malignancies in men, with dietary factors, particularly saturated fatty acids (SFAs), emerging as significant contributors to its pathogenesis. This review synthesizes current literature linking dietary fat intake, especially from dairy pro...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03005-0 |
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| author | Jia Wei He Zi Xuan Huang Yan Feng Su Yang Qi Mo |
| author_facet | Jia Wei He Zi Xuan Huang Yan Feng Su Yang Qi Mo |
| author_sort | Jia Wei He |
| collection | DOAJ |
| description | Abstract Prostate cancer (PCa) is one of the most prevalent malignancies in men, with dietary factors, particularly saturated fatty acids (SFAs), emerging as significant contributors to its pathogenesis. This review synthesizes current literature linking dietary fat intake, especially from dairy products, to increased prostate cancer risk, highlighting specific SFAs such as myristic and palmitic acids. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is identified as a critical mediator in this relationship, promoting cell survival and proliferation in the tumor microenvironment. Additionally, the role of the lipogenic enzyme ELOVL7 is explored, emphasizing its involvement in fatty acid metabolism and cancer progression. While epidemiological and mechanistic studies provide compelling evidence for the link between dietary SFAs and prostate cancer through NF-κB activation, significant knowledge gaps remain, necessitating further research to elucidate the underlying mechanisms and potential therapeutic strategies targeting lipid metabolism. |
| format | Article |
| id | doaj-art-a1497b6d2a1a42378b90bf6c860873b9 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a1497b6d2a1a42378b90bf6c860873b92025-08-20T03:47:13ZengSpringerDiscover Oncology2730-60112025-06-0116112110.1007/s12672-025-03005-0Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanismsJia Wei He0Zi Xuan Huang1Yan Feng Su2Yang Qi Mo3Dongguan Songshan Lake Central HospitalDongguan Songshan Lake Central HospitalDongguan Songshan Lake Central HospitalDongguan Songshan Lake Central HospitalAbstract Prostate cancer (PCa) is one of the most prevalent malignancies in men, with dietary factors, particularly saturated fatty acids (SFAs), emerging as significant contributors to its pathogenesis. This review synthesizes current literature linking dietary fat intake, especially from dairy products, to increased prostate cancer risk, highlighting specific SFAs such as myristic and palmitic acids. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is identified as a critical mediator in this relationship, promoting cell survival and proliferation in the tumor microenvironment. Additionally, the role of the lipogenic enzyme ELOVL7 is explored, emphasizing its involvement in fatty acid metabolism and cancer progression. While epidemiological and mechanistic studies provide compelling evidence for the link between dietary SFAs and prostate cancer through NF-κB activation, significant knowledge gaps remain, necessitating further research to elucidate the underlying mechanisms and potential therapeutic strategies targeting lipid metabolism.https://doi.org/10.1007/s12672-025-03005-0Prostate cancerSaturated fatty acidsNF-κB pathwayDietary factorsCancer progression. |
| spellingShingle | Jia Wei He Zi Xuan Huang Yan Feng Su Yang Qi Mo Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms Discover Oncology Prostate cancer Saturated fatty acids NF-κB pathway Dietary factors Cancer progression. |
| title | Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms |
| title_full | Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms |
| title_fullStr | Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms |
| title_full_unstemmed | Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms |
| title_short | Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms |
| title_sort | dietary saturated fatty acids and prostate cancer insights into nf κb pathway and lipid metabolism mechanisms |
| topic | Prostate cancer Saturated fatty acids NF-κB pathway Dietary factors Cancer progression. |
| url | https://doi.org/10.1007/s12672-025-03005-0 |
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