Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration

Abstract Carbon monoxide, as a crucial C1 synthon, has been widely used in the difunctionalization of alkenes. Additionally, nitrogen‐centered radicals (NCRs) are also effective intermediates for constructing C−N bonds. Herein, a nitrogen‐centered radical‐mediated aminative carbonylation strategy fo...

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Main Authors: Ming Hou, Yuanrui Wang, Hefei Yang, Jiajun Zhang, Prof. Dr. Xiao‐Feng Wu
Format: Article
Language:English
Published: Wiley-VCH 2025-05-01
Series:ChemistryEurope
Subjects:
Online Access:https://doi.org/10.1002/ceur.202500001
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author Ming Hou
Yuanrui Wang
Hefei Yang
Jiajun Zhang
Prof. Dr. Xiao‐Feng Wu
author_facet Ming Hou
Yuanrui Wang
Hefei Yang
Jiajun Zhang
Prof. Dr. Xiao‐Feng Wu
author_sort Ming Hou
collection DOAJ
description Abstract Carbon monoxide, as a crucial C1 synthon, has been widely used in the difunctionalization of alkenes. Additionally, nitrogen‐centered radicals (NCRs) are also effective intermediates for constructing C−N bonds. Herein, a nitrogen‐centered radical‐mediated aminative carbonylation strategy for producing β‐amino ketones from tertiary allyl alcohols has been disclosed. Good yields of β‐amino ketones with different functional groups were generated effectively under light irradiation.
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institution Kabale University
issn 2751-4765
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publishDate 2025-05-01
publisher Wiley-VCH
record_format Article
series ChemistryEurope
spelling doaj-art-a0dac8bde9ad41f1a9e44b9a2e317ee72025-08-20T03:49:45ZengWiley-VCHChemistryEurope2751-47652025-05-0133n/an/a10.1002/ceur.202500001Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl MigrationMing Hou0Yuanrui Wang1Hefei Yang2Jiajun Zhang3Prof. Dr. Xiao‐Feng Wu4Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics Chinese Academy of Sciences 116023 Dalian, Liaoning ChinaDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics Chinese Academy of Sciences 116023 Dalian, Liaoning ChinaDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics Chinese Academy of Sciences 116023 Dalian, Liaoning ChinaDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics Chinese Academy of Sciences 116023 Dalian, Liaoning ChinaDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics Chinese Academy of Sciences 116023 Dalian, Liaoning ChinaAbstract Carbon monoxide, as a crucial C1 synthon, has been widely used in the difunctionalization of alkenes. Additionally, nitrogen‐centered radicals (NCRs) are also effective intermediates for constructing C−N bonds. Herein, a nitrogen‐centered radical‐mediated aminative carbonylation strategy for producing β‐amino ketones from tertiary allyl alcohols has been disclosed. Good yields of β‐amino ketones with different functional groups were generated effectively under light irradiation.https://doi.org/10.1002/ceur.202500001nitrogen-centered radicalphotocatalysisunactivated alkenescarbonylationamination
spellingShingle Ming Hou
Yuanrui Wang
Hefei Yang
Jiajun Zhang
Prof. Dr. Xiao‐Feng Wu
Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration
ChemistryEurope
nitrogen-centered radical
photocatalysis
unactivated alkenes
carbonylation
amination
title Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration
title_full Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration
title_fullStr Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration
title_full_unstemmed Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration
title_short Photo‐Promoted Nitrogen‐Centered Radical Mediated Intermolecular Aminative Carbonylation of Tertiary Allyl Alcohols to Access β‐Amino Ketones through (Hetero)Aryl Migration
title_sort photo promoted nitrogen centered radical mediated intermolecular aminative carbonylation of tertiary allyl alcohols to access β amino ketones through hetero aryl migration
topic nitrogen-centered radical
photocatalysis
unactivated alkenes
carbonylation
amination
url https://doi.org/10.1002/ceur.202500001
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