Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review
Inflammation, oxidative stress, and metabolic diseases are intricately linked in a complex, self-reinforcing relationship. Inflammation can induce oxidative stress, while oxidative stress can trigger inflammatory responses, creating a cycle that contributes to the development and progression of meta...
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MDPI AG
2025-01-01
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| author | Rocio Guadalupe Hernández-Ruiz Xochitl Citalli Olivares-Ochoa Yahatziri Salinas-Varela David Guajardo-Espinoza Luis Gustavo Roldán-Flores Edgar Alfonso Rivera-Leon Andres López-Quintero |
| author_facet | Rocio Guadalupe Hernández-Ruiz Xochitl Citalli Olivares-Ochoa Yahatziri Salinas-Varela David Guajardo-Espinoza Luis Gustavo Roldán-Flores Edgar Alfonso Rivera-Leon Andres López-Quintero |
| author_sort | Rocio Guadalupe Hernández-Ruiz |
| collection | DOAJ |
| description | Inflammation, oxidative stress, and metabolic diseases are intricately linked in a complex, self-reinforcing relationship. Inflammation can induce oxidative stress, while oxidative stress can trigger inflammatory responses, creating a cycle that contributes to the development and progression of metabolic disorders; in addition, these effects can be observed at systemic and local scales. Both processes lead to cellular damage, mitochondrial dysfunction, and insulin resistance, particularly affecting adipose tissue, the liver, muscles, and the gastrointestinal tract. This results in impaired metabolic function and energy production, contributing to conditions such as type 2 diabetes, obesity, and metabolic syndrome. Legumes are a good source of phenolic compounds and anthocyanins that exert an antioxidant effect—they directly neutralize reactive oxygen species and free radicals, reducing oxidative stress. In vivo, in vitro, and clinical trial studies demonstrate that these compounds can modulate key cellular signaling pathways involved in inflammation and metabolism, improving insulin sensitivity and regulating lipid and glucose metabolism. They also exert anti-inflammatory effects by inhibiting proinflammatory enzymes and cytokines. Additionally, anthocyanins and phenolics may positively influence the gut microbiome, indirectly affecting metabolism and inflammation. |
| format | Article |
| id | doaj-art-a0da03b000d34e41aa5f4470c93bc9f3 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-a0da03b000d34e41aa5f4470c93bc9f32025-01-10T13:19:06ZengMDPI AGMolecules1420-30492025-01-0130117410.3390/molecules30010174Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive ReviewRocio Guadalupe Hernández-Ruiz0Xochitl Citalli Olivares-Ochoa1Yahatziri Salinas-Varela2David Guajardo-Espinoza3Luis Gustavo Roldán-Flores4Edgar Alfonso Rivera-Leon5Andres López-Quintero6Doctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, MexicoDoctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, MexicoDoctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, MexicoLicenciatura en Médico Cirujano y Partero, CUCS, UdeG, Guadalajara 44340, Jalisco, MexicoLicenciatura en Médico Cirujano y Partero, CUCS, UdeG, Guadalajara 44340, Jalisco, MexicoInstituto de Nutrigenética y Nutrigenómica Traslacional, CUCS, UdeG, Guadalajara 44340, Jalisco, MexicoDoctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, MexicoInflammation, oxidative stress, and metabolic diseases are intricately linked in a complex, self-reinforcing relationship. Inflammation can induce oxidative stress, while oxidative stress can trigger inflammatory responses, creating a cycle that contributes to the development and progression of metabolic disorders; in addition, these effects can be observed at systemic and local scales. Both processes lead to cellular damage, mitochondrial dysfunction, and insulin resistance, particularly affecting adipose tissue, the liver, muscles, and the gastrointestinal tract. This results in impaired metabolic function and energy production, contributing to conditions such as type 2 diabetes, obesity, and metabolic syndrome. Legumes are a good source of phenolic compounds and anthocyanins that exert an antioxidant effect—they directly neutralize reactive oxygen species and free radicals, reducing oxidative stress. In vivo, in vitro, and clinical trial studies demonstrate that these compounds can modulate key cellular signaling pathways involved in inflammation and metabolism, improving insulin sensitivity and regulating lipid and glucose metabolism. They also exert anti-inflammatory effects by inhibiting proinflammatory enzymes and cytokines. Additionally, anthocyanins and phenolics may positively influence the gut microbiome, indirectly affecting metabolism and inflammation.https://www.mdpi.com/1420-3049/30/1/174phenolic compoundsanthocyaninslegumesinflammationmetabolism |
| spellingShingle | Rocio Guadalupe Hernández-Ruiz Xochitl Citalli Olivares-Ochoa Yahatziri Salinas-Varela David Guajardo-Espinoza Luis Gustavo Roldán-Flores Edgar Alfonso Rivera-Leon Andres López-Quintero Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review Molecules phenolic compounds anthocyanins legumes inflammation metabolism |
| title | Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review |
| title_full | Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review |
| title_fullStr | Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review |
| title_full_unstemmed | Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review |
| title_short | Phenolic Compounds and Anthocyanins in Legumes and Their Impact on Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review |
| title_sort | phenolic compounds and anthocyanins in legumes and their impact on inflammation oxidative stress and metabolism comprehensive review |
| topic | phenolic compounds anthocyanins legumes inflammation metabolism |
| url | https://www.mdpi.com/1420-3049/30/1/174 |
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