Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

Abstract Cancer drug screening in patient‐derived cells holds great promise for personalized oncology and drug discovery but lacks standardization. Whether cells are cultured as conventional monolayer or advanced, matrix‐dependent organoid cultures influences drug effects and thereby drug selection...

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Main Authors: Julia Jabs, Franziska M Zickgraf, Jeongbin Park, Steve Wagner, Xiaoqi Jiang, Katharina Jechow, Kortine Kleinheinz, Umut H Toprak, Marc A Schneider, Michael Meister, Saskia Spaich, Marc Sütterlin, Matthias Schlesner, Andreas Trumpp, Martin Sprick, Roland Eils, Christian Conrad
Format: Article
Language:English
Published: Springer Nature 2017-11-01
Series:Molecular Systems Biology
Subjects:
cancer organoids
confocal microscopy
high‐throughput screening
personalized drug screen
pharmacogenomics
Online Access:https://doi.org/10.15252/msb.20177697
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https://doi.org/10.15252/msb.20177697

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