Summary measures in non-inferiority clinical trials with a time-to-event outcome: an empirical comparison of power

Summary measures in non-inferiority clinical trials with a time-to-event outcome: an empirical comparison of power

Abstract Background Time-to-event data is commonly used in non-inferiority clinical trials. While the hazard ratio is a popular summary measure in this context, the difference in restricted mean survival time has been theoretically shown to increase power and interpretability. This study aimed to em...

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Bibliographic Details
Main Authors: S. D. Lana Broer, Ian R. White, Tim P. Morris, Isabelle R. Weir, Marta Fiocco, Matteo Quartagno
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medical Research Methodology
Subjects:
Power
Non-inferiority
Time-to-event data
Proportional hazards
Hazard ratio
Difference in survival
Online Access:https://doi.org/10.1186/s12874-025-02576-4
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https://doi.org/10.1186/s12874-025-02576-4

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