The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models

The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models

IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by an overactive immune response, particularly involving excessive production of type I interferons. This overproduction is driven by the phosphorylation of IRF7, a crucial factor in interferon gene activation. Cur...

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Main Authors: Nassima Bekaddour, Nikaïa Smith, Birgit Caspar, Severine Grinberg, Stephane Giorgiutti, Vincent Rodeschini, Stephanie Dupuy, Nicolas Leboulanger, Darragh Duffy, Pauline Soulas-Sprauel, Vincent Gies, Anne-Sophie Korganow, Sébastien Nisole, Jean-Philippe Herbeuval
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
interferons
pDc
SLE
CXCR4
pIRF7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490593/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490593/full

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