Phthalazine based hydrazone as potent radical scavenger: Synthesis, spectral characterization, single crystal X-ray diffraction, DFT studies, molecular docking, ADME, antioxidant and antimicrobial activity of (E)-1-(2-substitutedbenzylidene)phthalazine derivatives

Phthalazine based hydrazone as potent radical scavenger: Synthesis, spectral characterization, single crystal X-ray diffraction, DFT studies, molecular docking, ADME, antioxidant and antimicrobial activity of (E)-1-(2-substitutedbenzylidene)phthalazine derivatives

This study examines the synthesis, structural and biological properties of phthalazine-derived hydrazone compounds. A series of hydrazone derivatives based on phthalazine (1a-h) were synthesized. FT-IR, 1H & 13C NMR, and Mass spectrometry were used to determine their structures, while Single...

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Bibliographic Details
Main Authors: Surya Uthrapathy, Balasankar Thirunavukkarasu, Kodisundaram Paulrasu, Tanzeer Ahmad Dar, Manikandan Palrasu, Morris Princey, Krishnapriya Thangaretnam, Vinoth Murali
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Results in Chemistry
Subjects:
Phthalazine-derived Hydrazone
Hydrazone Tautomer
DFT
Antioxidant
Antibacterial
ADME
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624006544
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