All-Printed Microfluidic–Electrochemical Devices for Glucose Detection
Free-standing capillary microfluidic channels were directly printed over printed electrodes using a particle/polymer mixture to fabricate microfluidic–electrochemical devices on polyethylene terephthalate (PET) films. Printed devices with no electrode modification were demonstrated to have the lowes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/14/12/569 |
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| author | Zexi Wang Zhiyi Zhang Changqing Xu |
| author_facet | Zexi Wang Zhiyi Zhang Changqing Xu |
| author_sort | Zexi Wang |
| collection | DOAJ |
| description | Free-standing capillary microfluidic channels were directly printed over printed electrodes using a particle/polymer mixture to fabricate microfluidic–electrochemical devices on polyethylene terephthalate (PET) films. Printed devices with no electrode modification were demonstrated to have the lowest limit of detection (LOD) of 7 μM for sensing glucose. The study shows that both a low polymer concentration in the mixture for printing the microfluidic channels and surface modification of the printed microfluidic channels using 3-aminopropyltrimethoxysilane can substantially boost the device’s performance. It also shows that both device structure and enzyme doping level of the devices play an important role in ensuring the best performance of the devices under various testing conditions. |
| format | Article |
| id | doaj-art-a08dba183c0c4eb9bb3864368c86ce6e |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-a08dba183c0c4eb9bb3864368c86ce6e2024-12-27T14:14:09ZengMDPI AGBiosensors2079-63742024-11-01141256910.3390/bios14120569All-Printed Microfluidic–Electrochemical Devices for Glucose DetectionZexi Wang0Zhiyi Zhang1Changqing Xu2School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4L8, CanadaQuantum and Nanotechnologies Research Center, National Research Council Canada, Ottawa, ON K1A 0R6, CanadaEngineering Physics, McMaster University, Hamilton, ON L8S 4L8, CanadaFree-standing capillary microfluidic channels were directly printed over printed electrodes using a particle/polymer mixture to fabricate microfluidic–electrochemical devices on polyethylene terephthalate (PET) films. Printed devices with no electrode modification were demonstrated to have the lowest limit of detection (LOD) of 7 μM for sensing glucose. The study shows that both a low polymer concentration in the mixture for printing the microfluidic channels and surface modification of the printed microfluidic channels using 3-aminopropyltrimethoxysilane can substantially boost the device’s performance. It also shows that both device structure and enzyme doping level of the devices play an important role in ensuring the best performance of the devices under various testing conditions.https://www.mdpi.com/2079-6374/14/12/569printingporous materialscapillary microfluidicelectrochemicalglucose sensing |
| spellingShingle | Zexi Wang Zhiyi Zhang Changqing Xu All-Printed Microfluidic–Electrochemical Devices for Glucose Detection Biosensors printing porous materials capillary microfluidic electrochemical glucose sensing |
| title | All-Printed Microfluidic–Electrochemical Devices for Glucose Detection |
| title_full | All-Printed Microfluidic–Electrochemical Devices for Glucose Detection |
| title_fullStr | All-Printed Microfluidic–Electrochemical Devices for Glucose Detection |
| title_full_unstemmed | All-Printed Microfluidic–Electrochemical Devices for Glucose Detection |
| title_short | All-Printed Microfluidic–Electrochemical Devices for Glucose Detection |
| title_sort | all printed microfluidic electrochemical devices for glucose detection |
| topic | printing porous materials capillary microfluidic electrochemical glucose sensing |
| url | https://www.mdpi.com/2079-6374/14/12/569 |
| work_keys_str_mv | AT zexiwang allprintedmicrofluidicelectrochemicaldevicesforglucosedetection AT zhiyizhang allprintedmicrofluidicelectrochemicaldevicesforglucosedetection AT changqingxu allprintedmicrofluidicelectrochemicaldevicesforglucosedetection |