Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolates

Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolates

ABSTRACT Trichomonas vaginalis is the most common non-viral sexually transmitted infection worldwide. We compared the in vitro activity of the thiazolide nitazoxanide (NTZ) and its metabolite, tizoxanide (TIZ), with the activity of the Food and Drug Administration-approved 5-nitroimidazoles (metroni...

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Main Authors: Keonte J. Graves, John C. Williamson, Jan Novak, Hemant K. Tiwari, W. Evan Secor, Christina A. Muzny
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
Trichomonas vaginalis
drug resistance
nitazoxanide
tizoxanide
5-nitroimidazole
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02717-24
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https://journals.asm.org/doi/10.1128/spectrum.02717-24

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