Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

Abstract Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and a ASMD patient. High SM reduced expression...

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Bibliographic Details
Main Authors: Adrián Bartoll, Ana Toledano‐Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesma
Format: Article
Language:English
Published: Springer Nature 2020-10-01
Series:EMBO Molecular Medicine
Subjects:
endocannabinoids
neurodegeneration
Niemann–Pick
sphingomyelin
Online Access:https://doi.org/10.15252/emmm.201911776
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https://doi.org/10.15252/emmm.201911776

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